A General Approach to Terminal Allenols

Abstract

We have demonstrated a very general method for the preparation of essentially any terminal 2,3-allenol from the corresponding alkynols, which may be easily available from propargylic alcohols by alkylation, or from terminal alkynes by deprotonation and 1,2-addition with aldehydes or ketones, and subsequent base-catalyzed triple-bond migration.

Key words

copper(I) iodide - dicyclohexylamine - allenols - long carbon chain - chirality

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