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Arzneimittelforschung 2012; 62(04): 167-175
DOI: 10.1055/s-0031-1299744
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Synthesis of Cyclopentapyridine and Thienopyridine Derivatives as Potential Calcium Channel Modulators

M. G. Gündüz
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
,
C. Şafak
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
,
B. Kaygısız
2   Department of Pharmacology, Faculty of Medicine, Osman Gazi University, Eskişehir, Turkey
,
B. Ç. Koşar
2   Department of Pharmacology, Faculty of Medicine, Osman Gazi University, Eskişehir, Turkey
,
R. Şimşek
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
,
K. Erol
2   Department of Pharmacology, Faculty of Medicine, Osman Gazi University, Eskişehir, Turkey
,
A. Linden
3   Institute of Organic Chemistry, University of Zurich Zurich, Switzerland
› Institutsangaben
Weitere Informationen

Publikationsverlauf

received 02. Dezember 2011

accepted 19. Dezember 2011

Publikationsdatum:
27. Januar 2012 (online)

    Lizenzen und Reprints

Abstract

In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1–21) or tetrahydrothiophene-1,1-dioxide ring (22–42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators.

Key words

1,4-Dihydropyridine - thienopyridine - cyclopentapyridine - calcium channel modulator
 

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