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Synlett 2012; 23(9): 1305-1308
DOI: 10.1055/s-0031-1290826
DOI: 10.1055/s-0031-1290826
letter
A General Regioselective Synthesis of 2,4-Diarylpyrimidines from 2- Thiouracil through Two Orthogonal Cross-Coupling Reactions
Weitere Informationen
Publikationsverlauf
Received: 21. Februar 2012
Accepted after revision: 08. März 2012
Publikationsdatum:
07. Mai 2012 (online)
![](https://www.thieme-connect.de/media/synlett/201209/lookinside/thumbnails/10.1055-s-0031-1290826-1.jpg)
Abstract
A novel efficient synthesis of 2,4-diarylpyrimidines was developed based on phosphonium-mediated Suzuki coupling of 2-(methylsulfanyl)pyrimidin-4(3H)-one (at position 4) followed by the Liebeskind–Srogl cross-coupling (at position 2) under microwave irradiation.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett. Included are a complete experimental section, and copies of NMR spectra and crystal structures.
- Supporting Information
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