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Synthesis 2010(16): 2721-2724
DOI: 10.1055/s-0030-1258150
DOI: 10.1055/s-0030-1258150
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
One-Pot Double Suzuki Couplings of Dichloropyrimidines
Further Information
Received
17 February 2010
Publication Date:
07 July 2010 (online)
Publication History
Publication Date:
07 July 2010 (online)
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Abstract
An effective one-pot, regioselective double Suzuki coupling of 2,4-dichloropyrimidine has been developed, which enables the quick and efficient synthesis of diarylated pyrimidines. The choice of solvent proved critical to the success of this reaction sequence, with alcoholic solvent mixtures affording much greater reactivity and requiring correspondingly lower temperatures than the use of polar aprotic solvents.
Key words
pyrimidines - Suzuki coupling - regioselectivity - palladium-catalyzed - one-pot reaction
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