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Synfacts 2011(12): 1372-1372
DOI: 10.1055/s-0031-1289421
DOI: 10.1055/s-0031-1289421
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Oxidative Amidation of Alcohols with Amines Catalyzed by Au/DNA
Y. Wang, D. Zhu, L. Tang, S. Wang*, Z. Wang*
University of Science and Technology of China, Hefei, P. R. of China
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
18. November 2011 (online)
Significance
An Au/DNA nanohybrid (1) catalyzed the oxidative amidation of alcohols with amines in the presence of LiOH˙H2O in water under oxygen atmosphere to afford the corresponding amides in up to 96% yield (31 examples). The catalyst was recovered by centrifugation and reused four times with slight loss of its catalytic activity for the oxidative amidation of aniline with benzyl alcohol (1st reuse; 89% yield, 2nd reuse; 85% yield, 3rd reuse; 82% yield, 4th reuse; 80% yield).