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Synfacts 2011(12): 1374-1374  
DOI: 10.1055/s-0031-1289414
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd/C-Catalyzed Hiyama Cross-Coupling

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Aya Ohno
T. Yanase, S. Mori, Y. Monguchi, H. Sajiki*
Gifu Pharmaceutical University, Japan
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

Pd/C (Pd particle size: 5 nm, carbon surface area: 1100 m²g-¹) with an electron-deficient phosphine ligand (4-FC6H4)3P catalyzed the Hiyama cross-coupling reaction of aryl halides 1 and aryltriethoxysilanes 2 to give the corresponding biaryl products 3 in up to 90% yield. A small amount of H2O mediated the reaction efficiency, while an excess amount of H2O rather retarded the reaction.