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Synfacts 2011(12): 1322-1322  
DOI: 10.1055/s-0031-1289382
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Helical Macromolecular Ligand for Asymmetric Suzuki Coupling

Contributor(s): Hisashi Yamamoto, Patrick Brady
T. Yamamoto, Y. Akai, Y. Nagata, M. Suginome*
Kyoto University and Japan Science and Technology Agency, Kyoto, Japan
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

The catalytic asymmetric synthesis of molecules with axial chirality is an ongoing challenge in organic synthesis. This report describes the palladium-catalyzed asymmetric synthesis of biaryls using macromolecular polymeric phosphine ligands, which in some cases outperform conventional monomeric phosphine ligands.