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Synfacts 2011(12): 1313-1313  
DOI: 10.1055/s-0031-1289360
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric α-Allylation of Aldehydes with Simple Allylic Alcohols

Contributor(s): Mark Lautens, Patrick T. Franke
G. Jiang, B. List*
Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

List and co-workers developed an enantioselective direct α-allylation of α-branched aldehydes with allylic alcohols generating products with all-carbon quaternary stereogenic centers in high yields and excellent enantioselectivities. The general reaction scale for this transformation is 0.2 mmol.