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DOI: 10.1055/s-0030-1271040
© Georg Thieme Verlag KG Stuttgart · New York
Two New Derivatives of Griseofulvin from the Mangrove Endophytic Fungus Nigrospora sp. (Strain No. 1403) from Kandelia candel (L.) Druce
Publikationsverlauf
received February 12, 2011
revised March 29, 2011
accepted March 31, 2011
Publikationsdatum:
21. April 2011 (online)
![](https://www.thieme-connect.de/media/plantamedica/201115/lookinside/thumbnails/10.1055-s-0030-1271040-1.jpg)
Abstract
Two new compounds, methyl 3-chloro-6-hydroxy-2-(4-hydroxy-2-methoxy-6-methylphenoxy)-4-methoxybenzoate (1) and (2S,5′R,E)-7-hydroxy-4,6-dimethoxy-2-(1-methoxy-3-oxo-5-methylhex-1-enyl)-benzofuran-3(2H)-one (2), together with four known compounds, griseofulvin (3), dechlorogriseofulvin (4), bostrycin (5), and deoxybostrycin (6), were isolated from the marine endophytic fungus Nigrospora sp. (No. 1403) collected from the South China Sea. The structures were elucidated by spectroscopic methods, 1D, 2D NMR, and HREIMS. Compounds 5 and 6 showed moderate antitumor and moderate antimicrobial activity.
Key words
Trichosphaeriaceae - Nigrospora sp. - Kandelia candel (L.) Druce - metabolites - cytotoxicity - antimicrobial activity
- Supporting Information for this article is available online at
- Supporting Information .
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Prof. Changheng Liu
Key Laboratory for Applied Microbiology of Shandong Province
Biotechnology Center of the Shandong Academy of Sciences
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Sun Yatsen University
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