J Knee Surg 2010; 23(2): 109-114
DOI: 10.1055/s-0030-1267465
CASE REPORT

© Thieme Medical Publishers

2-Year Postoperative Evaluation of a Patient with a Symptomatic Full-Thickness Patellar Cartilage Defect Repaired with Particulated Juvenile Cartilage Tissue

Kevin F. Bonner1 , William Daner1 , Jian Q. Yao2
  • 1Department of Orthopaedic Surgery, Eastern Virginia Medical School, Virginia Beach, Virginia
  • 2Zimmer Biologics, Austin, Texas
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Publikationsverlauf

Publikationsdatum:
22. Oktober 2010 (online)

ABSTRACT

This case report describes the early results of a 36-year-old man who underwent repair of a symptomatic full-thickness patellar cartilage defect with transplanted particulated juvenile articular cartilage. At 2 years postoperatively, the patient has experienced substantial clinical improvement in both pain and function when evaluated with both International Knee Documentation Committee subjective evaluation and Knee Injury and Osteoarthritis Outcome Score outcome measures. Two-year postoperative magnetic resonance imaging demonstrates fill of the defect with repair tissue and near complete resolution of preoperative subchondral bone edema. To the best of the authors' knowledge, this case report is the first to report clinical results of this new technique at 2 years postoperatively.

REFERENCES

  • 1 Moseley J B, O'Malley K, Petersen N J et al.. A controlled trial of arthroscopic surgery for osteoarthritis of the knee.  N Engl J Med. 2002;  347 81-88
  • 2 Mithoefer K, Williams III R J, Warren R F et al.. The microfracture technique for the treatment of articular cartilage lesions in the knee. A prospective cohort study.  J Bone Joint Surg Am. 2005;  87 1911-1920
  • 3 Steadman J R, Rodkey W G, Singleton S B, Briggs K K. Microfracture technique for full-thickness chondral defects. Technique and clinical results.  Oper Tech Orthop. 1997;  7 300-304
  • 4 Bobic V. [Autologous osteo-chondral grafts in the management of articular cartilage lesions].  Orthopade. 1999;  28 19-25
  • 5 Hangody L, Kish G, Kárpáti Z, Szerb I, Udvarhelyi I. Arthroscopic autogenous osteochondral mosaicplasty for the treatment of femoral condylar articular defects. A preliminary report.  Knee Surg Sports Traumatol Arthrosc. 1997;  5 262-267
  • 6 Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation.  N Engl J Med. 1994;  331 889-895
  • 7 Zaslav K, Cole B, Brewster R STAR Study Principal Investigators et al. A prospective study of autologous chondrocyte implantation in patients with failed prior treatment for articular cartilage defect of the knee: results of the Study of the Treatment of Articular Repair (STAR) clinical trial.  Am J Sports Med. 2009;  37 42-55
  • 8 Bugbee W D. Fresh osteochondral allografts.  J Knee Surg. 2002;  15 191-195
  • 9 Gross A E, Shasha N, Aubin P. Long-term followup of the use of fresh osteochondral allografts for posttraumatic knee defects.  Clin Orthop Relat Res. 2005;  (435) 79-87
  • 10 McNickle A G, Provencher MT, Cole BJ. Overview of existing cartilage repair technology.  Sports Med Arthrose. 2008;  16 196-201
  • 11 Williams III R J, Brophy R H. Decision making in cartilage repair procedures. In: Williams RJ 3rd, ed Cartilage Repair Strategies. Totowa, NJ; Humana Press Inc. 2007: 37-54
  • 12 Bentley G. Articular tissue grafts.  Ann Rheum Dis. 1992;  51 292-296
  • 13 Bentley G, Biant L C, Carrington R W et al.. A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee.  J Bone Joint Surg Br. 2003;  85 223-230
  • 14 Horas U, Pelinkovic D, Herr G, Aigner T, Schnettler R. Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint. A prospective, comparative trial.  J Bone Joint Surg Am. 2003;  85-A 185-192
  • 15 Knutsen G, Engebretsen L, Ludvigsen T C et al.. Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial.  J Bone Joint Surg Am. 2004;  86-A 455-464
  • 16 Saris D B, Vanlauwe J, Victor J et al.. Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture.  Am J Sports Med. 2008;  36 235-246
  • 17 Stockwell R A, Meachim G. The chondrocytes. In: Freeman MAR Adult Articular Cartilage. 2nd ed. Tunbridge Wells, England; Pitman Medical 1979: 69-144
  • 18 Feder J, Adkisson H D, Kizer N et al.. The promise of chondral repair using neocartilage. In: Sandell LJ, Grozinsky AJ Tissue Engineering in Musculoskeletal Clinical Practice. 1st ed. Rosemont, IL; American Association of Orthopaedic Surgeons 2004: 219-226
  • 19 Cheung H S, Cottrell W H, Stephenson K, Nimni M E. In vitro collagen biosynthesis in healing and normal rabbit articular cartilage.  J Bone Joint Surg Am. 1978;  60 1076-1081
  • 20 Namba R S, Meuli M, Sullivan K M, Le A X, Adzick N S. Spontaneous repair of superficial defects in articular cartilage in a fetal lamb model.  J Bone Joint Surg Am. 1998;  80 4-10
  • 21 Anderson A F, Irrgang J J, Kocher M S, Mann B J, Harrast J J. International Knee Documentation Committee . The International Knee Documentation Committee Subjective Knee Evaluation Form: normative data.  Am J Sports Med. 2006;  34 128-135
  • 22 Roos E M, Roos H P, Lohmander L S, Ekdahl C, Beynnon B D. Knee Injury and Osteoarthritis Outcome Score (KOOS)—development of a self-administered outcome measure.  J Orthop Sports Phys Ther. 1998;  28 88-96
  • 23 American Orthopaedic Society for Sports Medicine .Online IKDC scoring worksheet. Available at: http://www.sportsmed.org/tabs/research/ikdc.aspx Accessed May 30, 2009
  • 24 Knee injury and Osteoarthritis Outcome Score, Ewa Roos. Online KOOS scoring worksheet. Available at: http://www.koos.nu/index.html Accessed June 12, 2009
  • 25 Gudas R, Kalesinskas R J, Kimtys V et al.. A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes.  Arthroscopy. 2005;  21 1066-1075
  • 26 Nho S J, Foo L F, Green D M et al.. Magnetic resonance imaging and clinical evaluation of patellar resurfacing with press-fit osteochondral autograft plugs.  Am J Sports Med. 2008;  36 1101-1109
  • 27 Paul J, Sagstetter A, Kriner M, Imhoff AB, Spang J, Hinterwimmer S. Donor-site morbidity after osteochondrl autologous transplantation for lesions of the talus.  J Bone Joint Surg Ann. 2009;  91 1683-1688
  • 28 Minas T, Gomoll AH, Rosenberger R, Royce RO, Bryant T. Increased failure rate of autologous chondrocyte implantation after previous treatment with marrow stimlation techniques.  Am J Bone Sports Med. 2009;  37 907-908
  • 29 Bonner K F, Bugbee W D. Osteochondral allografting in the knee. In: Miller M, Cole B Textbook of Arthroscopy. Philadelphia, PA; Saunders 2004: 611-623
  • 30 Albrecht F, Roessner A, Zimmermann E. Closure of osteochondral lesions using chondral fragments and fibrin adhesive.  Arch Orthop Trauma Surg. 1983;  101 213-217
  • 31 Lu Y, Dhanaraj S, Wang Z et al.. Minced cartilage without cell culture serves as an effective intraoperative cell source for cartilage repair.  J Orthop Res. 2006;  24 1261-1270
  • 32 Frisbie D D, Lu Y, Colhoun H A, Kawcak C E, Binette F, McIlwraith C W. In vivo evaluation of a one step autologous cartilage resurfacing technique in a long term equine model. Presented at: Transactions of the 51st Annual Meeting of the Orthopaedic Research Society 2005 Washington, DC;
  • 33 Lewis P B, McCarty 3rd LP, Yao J Q, Williams J M, Kang R, Cole B J. Fixation of tissue-engineered human neocartilage constructs with human fibrin in a caprine model.  J Knee Surg. 2009;  22 196-204
  • 34 Farr J. DeNovo NT natural tissue graft. Presented at: Proceedings of the 8th World Congress of the International Cartilage Repair Society May 24–25, 2009 Miami, FL;
  • 35 U.S. Code of Federal Regulations, Title 21, Part 1271, Subpart D. “Good Tissue Practice”. U.S. Government Printing Office (GPO), April 2010
  • 36 Pearsall IV A W, Tucker J A, Hester R B, Heitman R J. Chondrocyte viability in refrigerated osteochondral allografts used for transplantation within the knee.  Am J Sports Med. 2004;  32 125-131

Kevin F BonnerM.D. 

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