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Synfacts 2011(10): 1112-1112
DOI: 10.1055/s-0030-1261071
DOI: 10.1055/s-0030-1261071
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Cu-Mediated Trifluoromethylation of Benzyl Bromides
H. Kawai, T. Furukawa, Y. Nomura, E. Tokunaga, N. Shibata*
Nagoya Institute of Technology, Japan
Further Information
Publication History
Publication Date:
20 September 2011 (online)
Significance
The authors describe a new copper-mediated trifluoromethylation reaction of primary benzyl bromides. The trifluoromethyl group is derived from an electrophilic trifluoromethylating reagent and is introduced chemoselectively at the benzylic position.