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Synfacts 2011(9): 0926-0926
DOI: 10.1055/s-0030-1260928
DOI: 10.1055/s-0030-1260928
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Lathyranoic Acid A
L.-F. Yu, H.-N. Hu, F.-J. Nan*
Shanghai Institute of Materia Medica, P. R. of China
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
19. August 2011 (online)

Significance
Lathyranoic acid A was isolated in 2005 from the seeds of Euphorbia lathyris and is one of a family of diterpenoids that possess a syn-cyclopropane ring and a 2-methylene-1,3-alkoxide as key functional moieties. This is the first total synthesis of lathyranoic acid A and was completed in 20 steps and 1.4% overall yield from known compounds.