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Synfacts 2011(9): 0995-0995
DOI: 10.1055/s-0030-1260878
DOI: 10.1055/s-0030-1260878
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Catalytic Regioselective Boration of α,β-Unsaturated Compounds
M. Gao, S. B. Thorpe, C. Kleeberg, C. Slebodnick, T. B. Marder, W. L. Santos*
Virginia Tech, Blacksburg, USA and Durham University, UK
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
19. August 2011 (online)

Significance
In this work, the development of an activated sp²-sp³ mixed-hybrid diboron reagent for the boration of α,β-unsaturated compounds is reported. This copper-catalyzed reaction proceeds under mild conditions and tolerates a variety of functionalities, such as nitriles, esters, ketones, and aldehydes. As neither copper-stabilizing additives nor boron-activating agents are required, this protocol is very economic and suitable for base-sensitive substrates.