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Synfacts 2011(2): 0186-0186
DOI: 10.1055/s-0030-1259263
DOI: 10.1055/s-0030-1259263
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper-Catalyzed Asymmetric Allylic Substitution with Arylaluminum Reagents
F. Gao, Y. Lee, K. Mandai, A. H. Hoveyda*
Boston College, Chestnut Hill, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
19. Januar 2011 (online)
![](https://www.thieme-connect.de/media/synfacts/201102/lookinside/thumbnails/10.1055-s-0030-1259263-1.jpg)
Significance
This work describes a highly efficient enantioselective allylic substitution of allyl phosphates. The reaction is catalyzed by an in situ generated copper-NHC complex and employs nucleophilic arylaluminum reagents, which are conveniently prepared from the corresponding aryllithium reagent. Chiral quaternary stereogenic centers are produced from readily available starting materials.