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Synthesis 2010(22): 3802-3810  
DOI: 10.1055/s-0030-1258314
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© Georg Thieme Verlag Stuttgart ˙ New York

Direct Addition of Functionalized Organozinc Reagents to Carbon Dioxide, Ketones, and Aldehydes in the Presence of MgCl2

Sebastian Bernhardt, Albrecht Metzger, Paul Knochel*
Ludwigs-Maximilians-Universität München, Department Chemie, Butenandtstraße 5-13, Haus F, 81377 München, Germany
Fax: +49(89)218077680; e-Mail: Paul.Knochel@cup.uni-muenchen.de;
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Publication History

Received 22 September 2010
Publication Date:
22 October 2010 (online)

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Abstract

A variety of functionalized organozinc reagents undergo smooth addition reactions at ambient temperature to carbon dioxide, ketones, and aldehydes in the presence of stoichiometric amounts of MgCl2. Several reactions were performed on a 20 mmol scale.

Key words

organozinc reagents - magnesium chloride - carbon dioxide - phenylacetic acid derivatives - addition reactions

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