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DOI: 10.1055/s-0030-1250122
© Georg Thieme Verlag KG Stuttgart · New York
Two New Lignans from the Roots of Pulsatilla koreana
Publikationsverlauf
received April 26, 2010
revised June 8, 2010
accepted June 12, 2010
Publikationsdatum:
19. Juli 2010 (online)
![](https://www.thieme-connect.de/media/plantamedica/201101/lookinside/thumbnails/10.1055-s-0030-1250122-1.jpg)
Abstract
Two new lignans, (2R,3R)-2β-(4′′-hydroxy-3′′-methoxybenzyl)-3α-(4′-hydroxy-3′-methoxybenzyl)-γ-butyrolactone 2-O-(β-D-glucopyranoside) (1) and (1S,2R,3S)-dimethyl-1,2,3,4-tetrahydro-3,6,7-trihydroxy-1-(3′,4′-dihydroxyphenyl)naphthalene-2,3-dicarboxylate (2) together with nine known compounds (3–11) were isolated from the ethyl acetate fraction of the roots of Pulsatilla koreana. Their chemical structures were established based on physicochemical and spectroscopic data analyses. All isolates were investigated for their inhibition effects against the classical pathway of the complement system. Among them, compound 6 showed significant inhibitory activity with an IC50 value of 75.9 µM, compounds 8 and 9 had moderate effects with IC50 values of 182.2 and 166.5 µM, respectively.
Key words
Pulsatilla koreana - Ranunculaceae - lignan - anticomplement activity
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Prof. KiHwan Bae
College of Pharmacy
Chungnam National University
305-764 Daejeon
Korea
Telefon: +82 4 28 21 59 25
Fax: +82 4 28 23 65 66
eMail: baekh@cnu.ac.kr
Prof. Byung Sun Min
College of Pharmacy
Catholic University of Daegu
330 Geumnak 1-ri
712-702 Gyeongbuk
Korea
Telefon: +82 5 38 50 36 13
Fax: +82 5 38 50 36 02
eMail: bsmin@cu.ac.kr