A General Catalyst System for Amination of Aryl Chlorides

R. J. Lundgren; A. Sappong-Kumankumah; M. Stradiotto

doi:10.1055/s-0029-1219677

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Synfacts 2010(5): 0580-0580
DOI: 10.1055/s-0029-1219677

Metal-Mediated Synthesis

A General Catalyst System for Amination of Aryl Chlorides

Contributor(s): Paul Knochel, Tobias Thaler
R. J. Lundgren, A. Sappong-Kumankumah, M. Stradiotto*
Dalhousie University, Nova Scotia, Canada

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Publication History

Publication Date:
22 April 2010 (online)

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Significance

Combinations of L1 or L2 with [Pd(allyl)Cl]₂ or [Pd(cinnamyl)Cl]₂ were found to be highly efficient and general catalyst systems for the Hartwig-Buchwald amination of (hetero)aryl chlorides. L1 and L2 are air-stable.