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Synfacts 2010(5): 0554-0554
DOI: 10.1055/s-0029-1219638
DOI: 10.1055/s-0029-1219638
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Iridium-Catalyzed Asymmetric Hydrogenation of Benzophenone N-H Imines
G. Hou, R. Tan, Y. Sun, X. Zhang*, F. Gosselin*
Merck Research Laboratories, Rahway and Rutgers, The State University of New Jersey, Piscataway, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. April 2010 (online)
Significance
The authors presented a direct, protection-free approach to the synthesis of chiral diarylmethylamines by asymmetric hydrogenation of benzophenone N-H imines. By using commercially accessible, low-cost chiral monodentate phosphoramidite ligands, chiral diarylmethylamine derivates were obtained with high yield and enantioselectivity.