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Synfacts 2009(11): 1287-1287
DOI: 10.1055/s-0029-1218067
DOI: 10.1055/s-0029-1218067
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Nitriles from Primary Alcohols and NH3 with Ru(OH)x/Al2O3
T. Oishi, K. Yamaguchi, N. Mizuno*
The University of Tokyo and Science and Technology Agency, Saitama, Japan
Further Information
Publication History
Publication Date:
22 October 2009 (online)
Significance
An Al2O3-supported ruthenium hydroxide catalyst (Ru(OH)x/Al2O3) promoted the reaction of primary alcohols 1 or aldehydes 2 with ammonia to give the corresponding nitriles 3 in 65-96% yield (from 1, 13 examples; from 2, 7 examples). No leaching of ruthenium was observed by ICP-AES analysis after the reaction.