MonoSil Microreactor for Knoevenagel Reaction and Transesterification

A. El Kadib; R. Chimenton; A. Sachse; F. Fajula; A. Galarneau; B. Coq

doi:10.1055/s-0029-1217652

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Synfacts 2009(9): 1053-1053
DOI: 10.1055/s-0029-1217652

Polymer-Supported Synthesis

MonoSil Microreactor for Knoevenagel Reaction and Transesterification

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada
A. El Kadib, R. Chimenton, A. Sachse, F. Fajula, A. Galarneau, B. Coq*
Institut Charles Gerhardt Montpellier, France

Further Information

Publication History

Publication Date:
21 August 2009 (online)

Permissions and Reprints

Significance

Functionalized monolithic mesoporous silicas, NH₂-MonoSil and HSO₃-MonoSil, were applied to the microreactor matrices for Knoevenagel reaction and transesterification, respectively. Thus, the Knoevenagel reaction of benzaldehyde with ethyl cyanoacetate in the NH₂-MonoSil-installed microreactor with 0.5 mL/min of flow rate gave ethyl α-cyanocinnamate in 84% for 28 h on stream (TON = 2280). The transesterification of triacetin with methanol was performed in the HSO₃-MonoSil-installed microreactor at 333 K to afford glycerol in 79% yield.