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Synfacts 2009(9): 0939-0939  
DOI: 10.1055/s-0029-1217621
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Sporolide B

Contributor(s): Philip Kocienski
K. C. Nicolaou*, Y. Tang, J. Wang
The Scripps Research Institute, La Jolla and University of California, San Diego, USA
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Publication History

Publication Date:
21 August 2009 (online)

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Significance

Sporolide B is a marine metabolite with no apparent biological activity. The Scripps synthesis uses a ruthenium-catalyzed [2+2+2] ­cycloaddition to generate the chlorinated arene ring in G and an intramolecular Diels-Alder reaction of the ortho-quinone H.