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Synfacts 2009(9): 0947-0947  
DOI: 10.1055/s-0029-1217609
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Antiostatin B2

Contributor(s): Philip Kocienski, Arndt W. Schmidt
K. E. Knott, S. Auschill, A. Jäger, H.-J. Knölker*
Technische Universität Dresden, Germany
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Publication History

Publication Date:
21 August 2009 (online)

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Significance

The antiostatins were isolated from Streptomyces cyaneus 2007-SV1. They are strong inhibitors of lipid peroxidation. The antio­statins differ in the alkyl side chain at C1 with the A series having a simple acetamide substituent at C4, while the B series has the iso-butylbiuret side chain at C4 as shown. In this paper the first total synthesis of all known antiostatins in the A and B series is reported.