Subscribe to RSS
DOI: 10.1055/s-0029-1210610
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Stimulatory Effect of Intracerebroventricularly Administered Dopamine on Vasopressin Release in Rats
Publication History
1986
Publication Date:
16 July 2009 (online)
Summary
Experiments were designed to investigate the effects of the intracerebroventricular administration of dopamine (DA) and a DA antagonist (pimozide) on the immunoreactive-vasopressin (IR-VP) contents of the rat magnocellular nuclei (MCN), neurohypophysis (NH) and plasma. The IR-VP levels in the MCN and NH were decreased 5 min after administration of DA in a dose of 20 nmol, but that in the plasma was increased. This effect was not observed after pretreatment with pimozide. Administration of pimozide alone did not affect the IR-VP contents of the MCN, NH or plasma. The results suggest that DA given icv. has a stimulatory effect on VP release from the neurohypophysial system.
Key words
Vasopressin - Dopamine - Magnocellular nuclei - Neurohypophysis