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DOI: 10.1055/s-0029-1186026
© Georg Thieme Verlag KG Stuttgart · New York
Lupane-Type Triterpene Glycosides from the Leaves of Acanthopanax koreanum and Their In Vitro Cytotoxicity
Publikationsverlauf
received May 4, 2009
revised July 8, 2009
accepted July 10, 2009
Publikationsdatum:
10. August 2009 (online)
![](https://www.thieme-connect.de/media/plantamedica/201002/lookinside/thumbnails/10.1055-s-0029-1186026-1.jpg)
Abstract
Three new lupane triterpene glycosides, acankoreosides J–L (1–3), were isolated from the leaves of Acanthopanax koreanum. Based on the spectroscopic data, the chemical structures were determined as 3α-hydroxy-20-oxo-30-norlupane-23,28-dioic 28-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (1); 3α,20,29-trihydroxylupane-23,28-dioic 28-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (2); and (20S)-3α-hydroxy-29,29-dimethoxylupane-23,28-dioic 28-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (3). Compounds 1−3 were evaluated for their cytotoxicity and showed moderate activity against four cell lines, A549 (lung), HL-60 (leukemia), MCF-7 (breast), and U937 (leukemia), with IC50 values of 23.4, 36.5, 22.6, and 18.5 µM for 1; 6.8, 18.6, 23.1, and > 100 µM for 2; and 28.9, 21.8, 11.0, and 27.5 µM for 3, respectively.
Key words
Acanthopanax koreanum - Araliaceae - lupane glycoside - acankoreoside - in vitro cytotoxic activity
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Prof. Dr. Young Ho Kim
College of Pharmacy
Chungnam National University
305-764 Daejeon
Korea
Telefon: + 82 4 28 21 59 33
Fax: + 82 4 28 23 65 66
eMail: yhk@cnu.ac.kr