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Synlett 2009(7): 1081-1086
DOI: 10.1055/s-0028-1088110
DOI: 10.1055/s-0028-1088110
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Monoarylation of Dibromoarenes by Simple Palladium Catalyst Systems: Efficient Synthesis of Bromobiaryls from Dibromoarenes and Arylboronic Acids
Further Information
Received
16 January 2009
Publication Date:
26 March 2009 (online)
Publication History
Publication Date:
26 March 2009 (online)
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Abstract
The Pd/C/Ph3P- and Pd(PPh3)4/Ph3P-catalyzed cross-couplings of dibromoarenes with arylboronic acids to form bromobiaryls in good to excellent yields are described. Our study showed that readily available Pd/C/Ph3P and Pd(PPh3)4/Ph3P were practically useful catalysts for the synthesis of bromobiaryls from dibromoarenes.
Key words
palladium - cross-coupling - dibromoarenes - monoarylation - arylboronic acids
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References and Notes
We have also tested Pd/C/Ph3P- and Pd(PPh3)4/Ph3P-catalyzed cross-coupling reactions of o-bromoiodobenzenes with arylboronic acids and found bromobiaryls were formed exclusively with excellent yields.