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Synthesis 2009(7): 1220-1223  
DOI: 10.1055/s-0028-1087996
PSP
© Georg Thieme Verlag Stuttgart ˙ New York

A New Atom-Economical and Selective Synthesis of Secondary and Tertiary Alkylamines by Means of Cp*Iridium Complex Catalyzed Multiple N-Alkylation of Ammonium Salts with Alcohols without Solvent

Ryohei Yamaguchi*, Zhu Mingwen, Shoko Kawagoe, Chiho Asai, Ken-ichi Fujita*
Graduate School of Human and Environmental Studies, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan
Fax: +81(75)7537861; e-Mail: yama@kagaku.mbox.media.kyoto-u.ac.jp; e-Mail: fujitak@kagaku.mbox.media.kyoto-u.ac.jp;
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Publication History

Received 13 November 2008
Publication Date:
06 March 2009 (online)

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Abstract

A new atom-economical and selective synthetic method for secondary and tertiary alkylamines has been achieved by means of (pentamethylcyclopentadienyl)iridium (Cp*Ir) complex catalyzed multiple N-alkylations of ammonium salts with primary and secondary alcohols without solvent.

Key words

ammonium salt - alcohol - amine - N-alkylation - iridium complex

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