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Synfacts 2009(3): 0317-0317  
DOI: 10.1055/s-0028-1087702
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Iron-Catalyzed Enyne Cross-Coupling Reaction

Contributor(s): Paul Knochel, Andrei Gavryushin
T. Hatakeyama, Y. Yoshimoto, T. Gabriel, M. Nakamura*
Kyoto University, Japan
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Publication History

Publication Date:
19 February 2009 (online)

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Significance

Alkynyl Grignard reagents, obtained in situ from the corresponding terminal alkynes, react in the presence of FeCl3 with a variety of alkenyl bromides and triflates in tetrahydrofuran under mild conditions. The resulting conjugated enynes are important structural units of organic electronic materials as well as various bioactive molecules. This reaction is suitable for a broad range of substrates.