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Synfacts 2009(3): 0316-0316  
DOI: 10.1055/s-0028-1087701
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Cu-NHC-Catalyzed Amination of Aryl and Heteroaryl Bromides with NH3

Contributor(s): Paul Knochel, Andrei Gavryushin
R. Ntaganda, B. Dhudshia, C. L. B. Macdonald, A. N. Thadani*
University of Windsor, Canada
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Publication History

Publication Date:
19 February 2009 (online)

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Significance

Various aryl and heteroaryl bromides can be transformed by the cross-coupling with ammonia in the presence of a readily available copper-NHC catalyst into the corresponding arylamines. The method does not require expensive ligands or metals, is suitable for scaling-up and tolerates most functionalities. The use of aryl bromides instead of more expensive iodides is ­another advantage of this method.