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Synfacts 2009(3): 0240-0240
DOI: 10.1055/s-0028-1087693
DOI: 10.1055/s-0028-1087693
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of ()-Neostenine
M. D. Lainchbury, M. I. Medley, P. M. Taylor, P. Hirst, W. Dohle, K. I. Booker-Milburn*
University of Bristol, UK
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
19. Februar 2009 (online)
Significance
Neostenine belongs to the Stemona alkaloids, which are isolated from the Stemonacae plants. Extracts of these plants have been used in Chinese and Japanese folk medicine for the treatment of bronchitis, tuberculosis and parasitic infestations. In this synthesis the pyrrolo[1,2-a]azepine core is constructed by a photochemically-induced [5+2] cycloaddition.