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Pharmacopsychiatry
DOI: 10.1055/a-2479-9430
Original Paper

Exposure to Psychotropic Drugs and Colorectal Cancer Risk in Patients with Affective Disorder: A Nested Case-Control Study

Tien-Wei Hsu
1   Department of Psychiatry, E-Da Dachang Hospital, I-Shou University, Kaohsiung, Taiwan
2   Department of Psychiatry, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan
,
Shih-Jen Tsai
3   Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
4   Department of Psychiatry, School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
,
Tzeng-Ji Chen
5   Department of Family Medicine, Taipei Veterans General Hospital, Hsinchu Branch, Hsinchu, Taiwan
6   Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan
,
Mu-Hong Chen    #
3   Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
4   Department of Psychiatry, School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
,
Chih-Sung Liang    #
7   Department of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
8   Department of Psychiatry, National Defense Medical Center, Taipei, Taiwan
› Institutsangaben Funding Hsinchu Science Park Bureau, Ministry of Science and Technology, Taiwan — http://dx.doi.org/10.13039/501100021806; 107–2314-B-075-063-MY3, 108-2314-B-075 -037 Yen Tjing Ling Industrial Research Institute, National Taiwan University — http://dx.doi.org/10.13039/501100006732; CI-109-21, CI-109-22, CI-110-30 Taipei Veterans General Hospital — http://dx.doi.org/10.13039/501100011912; V106B-020, V107B-010, V107C-181, V108B-012, V110C-
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Abstract

Background This study aimed to assess the association between the risk of colorectal cancer (CRC) and exposure to mood stabilizers, antidepressants, and antipsychotics in patients with affective disorders.

Methods This nested case-control study used data from the National Health Insurance Database of Taiwan collected between 2001 and 2011. All participants in this study had affective disorders. Then, 1209 patients with CRC and 1:10 matched controls were identified based on their demographic and clinical characteristics. A logistic regression model adjusted for demographic and clinical characteristics was used to determine the risk of developing CRC after exposure to psychotropic drugs.

Results Among patients with affective disorders, exposure to mood stabilizers (reported as odds ratio; 95% confidence interval; 0.75; 0.57–0.98), antidepressants (0.83; 0.70–0.97), second-generation antipsychotics (0.67; 0.52–0.86), and first-generation antipsychotics (0.65; 0.52–0.81) were associated with a reduced risk of CRC compared to patients who were not exposed. When considering specific drugs, carbamazepine (0.34; 0.12–0.95), valproic acid (0.66; 0.46–0.95), gabapentin (0.44; 0.20–0.99), fluoxetine (0.82; 0.68–0.99), paroxetine (0.63; 0.45–0.87), and venlafaxine (0.72; 0.55–0.95) were associated with a lower risk of CRC.

Conclusion Exposure to psychotropic drugs in patients with affective disorders is associated with a lower risk of CRC compared to those who were not exposed. Although the causal relationship between psychotropic drug exposure and reduced risk of CRC could not be inferred directly, these findings may help clinicians and patients in clinical decision-making.

Keywords

colorectal cancer - affective disorder - mood stabilizer - antidepressant - antipsychotic

# Mu-Hung Chen and Chih-Sung Liang are co-corresponding authors of this paper and have contributed equally in this capacity.


Supplementary Material



Publikationsverlauf

Eingereicht: 06. August 2024
Eingereicht: 19. Oktober 2024

Angenommen: 12. November 2024

Artikel online veröffentlicht:
17. Dezember 2024

© 2024. Thieme. All rights reserved.

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Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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