Enterovirus Infection in Preterm Quadruplets with Clinical Presentation of Neonatal Late-Onset Sepsis: a Case Report

Abstract

This is the unusual case of concurrent late-onset sepsis caused by enteroviruses in preterm quadruplets in a neonatal ward. While viral infections are an important differential diagnosis of bacterial sepsis in the outpatient setting, the occurrence in a neonatal ward with strict prophylactic hygiene measures is unusual. In this case, transmission of enteroviruses via breast milk appears possible.

Keywords

enterovirus - infection - neonatology - sepsis

Publication History

Received: 18 November 2023

Accepted after revision: 18 February 2024

Article published online:
15 April 2024

• References

• 1 Civardi E, Tzialla C, Baldanti F. et al. Viral outbreaks in neonatal intensive care units: what we do not know. Am J Infect Control 2013; 41: 854-856 DOI: 10.1016/j.ajic.2013.01.026.
• 2 Hassan M, Khalil A, Magboul S. et al. Neonates and young infants with COVID-19 presented with sepsis-like syndrome: a retrospective case controlled study. Front Pediatr 2021; 9: 634844 DOI: 10.3389/fped.2021.634844.
• 3 de Jong EP, van den Beuken MGA, van Elzakker EPM. et al. Epidemiology of sepsis-like illness in young infants: major role of enterovirus and human parechovirus. Pediatr Infect Dis J 2018; 37: 113-118 DOI: 10.1097/INF.0000000000001718.
• 4 Kidszun A, Klein L, Winter J. et al. Viral infections in neonates with suspected late-onset bacterial sepsis-a prospective cohort study. Am J Perinatol 2017; 34: 1-7 DOI: 10.1055/s-0036-1584150.
• 5 Verboon-Maciolek MA, Thijsen SFT, Hemels MAC. et al. Inflammatory mediators for the diagnosis and treatment of sepsis in early infancy. Pediatr Res 2006; 59: 457-461 DOI: 10.1203/01.pdr.0000200808.35368.57.
• 6 Maus MV, Posencheg MA, Geddes K. et al. Detection of echovirus 18 in human breast milk. J Clin Microbiol 2008; 46: 1137-1140 DOI: 10.1128/JCM.01991-07.