Kommentar zu „Intravenöse Vitamin C-Gabe: 28-Tage-Ergebnis septischer Patienten verschlechtert?“

Rarely the results of a study were expected so eagerly as the LOVIT trial, an acronym for “Lessening Organ Dysfunction with Vitamin C” [1]. This blinded multicentric randomised trial (RCT) is a well-performed study [1] testing high-dose intravenous vitamin C (IVVC) (50 mg/kg every 6 h for 96hrs). With 872 patients, the trial is the largest so far. The results are sobering, as the patients receiving IVVC had a worse primary composite outcome compared to the placebo group: of note, the different components of the outcome (death or persistent organ dysfunction), did not differ significantly when considered individually [2].

Publikationsverlauf

Artikel online veröffentlicht:
14. Dezember 2022

• References

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