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DOI: 10.1055/a-1736-8721
Palladium-Catalyzed Semihydrogenation of Alkynes with EtOH: Highly Stereoselective Synthesis of E- and Z-Alkenes
This work was supported in part by grants from the National Natural Science Foundation of China (82001606 to C.N.W., 81901540 to X.Z.), ‘333 Project’ Scientific Research Project of Jiangsu Province (BRA2020204 to D.W.X.), and Key Medical Talents Financial Assistance of Nantong (to D.W.X.).
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Abstract
A palladium-catalyzed semihydrogenation of alkynes to E- and Z-alkenes employing EtOH as the hydrogenating agent is reported. The selectivity of the reaction system was effectively controlled by ligand/additive and solvent regulation. The use of sodium acetate/triethanolamine (NaOAc/TEOA), THF, and (1R,2R)-bis[(2-methoxyphenyl)phenylphosphino]ethane [(R,R)-DIPAMP] in CH3CN was critical for the stereoselective semihydrogenation of alkynes. The general applicability of this procedure was highlighted by the synthesis of more than 36 alkenes, in good yields with high stereoselectivities.
Keywords
semihydrogenation - alkynes - palladium-catalyzed - highly stereoselective - EtOH as a hydrogen sourceSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1736-8721.
- Supporting Information
Publikationsverlauf
Eingereicht: 15. November 2021
Angenommen nach Revision: 11. Januar 2022
Accepted Manuscript online:
11. Januar 2022
Artikel online veröffentlicht:
14. März 2022
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