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Pharmacopsychiatry 2020; 53(04): 162-173
DOI: 10.1055/a-0975-9595
Review

Clinical Utilization of Pharmacogenetics in Psychiatry – Perspectives of Pharmacists, Genetic Counselors, Implementation Science, Clinicians, and Industry

Lisa Brown
1   Myriad Neuroscience, Myriad Genetics Inc, Salt Lake City, United States
,
Seenae Eum
2   Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, United States
,
Susanne B. Haga
3   Duke University School of Medicine, Durham, United States
,
Jeffrey R. Strawn
4   Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati, Cincinnati, United States
,
Heather Zierhut
2   Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, United States
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Abstract

Introduction The use of pharmacogenomic (PGx) testing to guide decisions and improve patient outcomes has increased in recent years. PGx testing represents a decision support tool that may inform dosing, increase the likelihood of treatment response, and identify patients at risk for medication side effects.

Methods This is a narrative review of utilization of PGx testing in psychiatry from stakeholders including, pharmacists, genetic counselors, implementation scientists, industry, and clinicians.

Results While many limitations exist to streamline use of PGx testing in psychiatry, various stakeholders are crucial to clinical implementation.

Discussion PGx testing can assist in medication selection and improve patient outcomes; however, more data are needed to understand when and how to incorporate PGx testing into psychiatric practice.

Key words

pharmacogenomics - pharmacogenetics - implementation


Publication History

Received: 01 April 2019
Received: 02 July 2019

Accepted: 09 July 2019

Article published online:
11 September 2019

© Georg Thieme Verlag KG
Stuttgart · New York

 

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