Download PDF
Thromb Haemost 2008; 100(01): 156-157
DOI: 10.1160/TH08-03-0132
Case Report
Schattauer GmbH

Intoxication with three different superwarfarin compounds in an adult woman

Marek Zolcinski
1   Department of Medicine, Jagiellonian University Medical College, Krakow, Poland
,
Agnieszka Padjas
1   Department of Medicine, Jagiellonian University Medical College, Krakow, Poland
,
Jacek Musial
1   Department of Medicine, Jagiellonian University Medical College, Krakow, Poland
› Author Affiliations
Further Information

Publication History

Received: 04 March 2008

Accepted after minor revision: 12 May 2008

Publication Date:
22 November 2017 (online)

    Permissions and Reprints

 

 

  • References

  • 1 Caravati EM. et al. Long-acting anticoagulant rodenticide poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol 2007; 45: 1-22.
    CrossrefPubMedGoogle Scholar
  • 2 Sharma P, Bentley P. Of rats and men: superwarfarin toxicity. Lancet 2005; 365: 552-553.
    CrossrefPubMedGoogle Scholar
  • 3 Chua JD, Friedenberg WR. Superwarfarin poisoning. Arch Intern Med 1998; 158: 1929-1932.
    CrossrefPubMedGoogle Scholar
  • 4 International Programme on Chemical Safety. Brodifacoum. http://www.inchem.org/documents/pds/pds/pest57_e.htm Accessed on February 18, 2008
    PubMedGoogle Scholar
  • 5 Watson WA. et al. 2004 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 2005; 23: 589-666.
    CrossrefPubMedGoogle Scholar
  • 6 Weitzel JN. et al. Surreptitious ingestion of a long-acting vitamin K antagonist/rodenticide, brodifacoum: clinical and metabolic studies of three cases. Blood 1990; 76: 2555-2559.
    PubMedGoogle Scholar
  • 7 Park BK. et al. Abnormal vitamin K metabolism in the presence of normal clotting factor activity in factory workers exposed to 4-hydroxycoumarins. Br J Clin Pharmacol 1986; 21: 289-293.
    CrossrefPubMedGoogle Scholar
  • 8 Spiller HA. et al. Dermal absorption of a liquid diphacinone rodenticide causing coagulaopathy. Vet Hum Toxicol 2003; 45: 313-314.
    PubMedGoogle Scholar
  • 9 Waien SA. et al. Severe coagulopathy as a consequence of smoking crack cocaine laced with rodenticide. N Engl J Med 2001; 345: 700-701.
    PubMedGoogle Scholar
  • 10 Laposata M. et al. Case 1–2007. A 40-year-old woman with epistaxis, hematemesis, and altered mental status. N Engl J Med 2007; 356: 174-182.
    CrossrefPubMedGoogle Scholar
  • 11 Pavlu J. et al. Superwarfarin poisoning. Lancet 2005; 365: 628.
    CrossrefPubMedGoogle Scholar
  • 12 Kotsaftis P. et al. Haemarthrosis after superwarfarin poisoning. Eur J Haematol 2007; 79: 255-257.
    CrossrefPubMedGoogle Scholar
  • 13 Hoffman RS. et al. Evaluation of coagulation factor abnormalities in long-acting anticoagulant overdose. J Toxicol Clin Toxicol 1988; 26: 233-248.
    CrossrefPubMedGoogle Scholar
  • 14 Tsutaoka BT. et al. Superwarfarin and glass ingestion with prolonged coagulopathy requiring high-dose vitamin K1 therapy. Pharmacotherapy 2003; 23: 1186-1189.
    CrossrefPubMedGoogle Scholar
  • 15 Geisen C. et al. VKORC1 haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulation. Thromb Haemost 2005; 94: 773-779.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 16 Oldenburg J. et al. Current pharmacogenetic developments in oral anticoagulation therapy: the influence of variant VKORC1 and CYP2C9 alleles. Thromb Haemost 2007; 98: 570-578.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 17 Vecsler M. et al. Combined genetic profiles of components and regulators of the vitamin K-dependent gamma-carboxylation system affect individual sensitivity to warfarin. Thromb Haemost 2006; 95: 205-211.
    Article in Thieme ConnectPubMedGoogle Scholar