Anti-Ulcer Effect of Steroidal Alkaloids Extracted from Pachysandra terminalis

H. Watanabe; K. Watanabe; M. Shimadzu; T. Kikuchi; Z. Liu

doi:10.1055/s-2007-969070

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Planta Med 1986; 52(1): 56-58
DOI: 10.1055/s-2007-969070

Communications

Anti-Ulcer Effect of Steroidal Alkaloids Extracted from Pachysandra terminalis

H. Watanabe¹ , K. Watanabe² , M. Shimadzu¹ , T. Kikuchi¹ , Z. Liu³

¹Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Toyama, 930-01, Japan
²Faculty of Pharmaceutícal Sciences, Chiba University, Chiba 260, Japan
³Institute of Traditional Chinese Medicine, Harbin, Heilongjiang Province, The People's Republic of China

Weitere Informationen

Publikationsverlauf

1985

Publikationsdatum:
26. Februar 2007 (online)

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Abstract

Effects on gross behaviour and experimental ulcers of five Steroidal alkaloids of pregnane type extracted from Pachysandra terminalis (Buxaceae), which has been used in Ainu's folk medicine for gastrointestinal diseases, were investigated in mice. Pachystermine A, pachysamine A and epipachysamine A produced sedation, tremor and clonic convulsions. Pachysandrine A and spiropachysine induced only mild sedation. The alkaloids exerted preventive effects on gastric lesions induced by restraint plus water-immersion stress. These results suggest that the alkaloids may contribute partly to traditional use of the plants for the gastrointestinal complaints.

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