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Planta Med 1992; 58(1): 26-30
DOI: 10.1055/s-2006-961383
Paper

© Georg Thieme Verlag Stuttgart · New York

The Effect of N-Deacetylcolchiceine on Serum Lipoproteins in Rats

Nina Škottová, Rostislav Večeřa, Daniela Walterová, Vilím Šimánek
  • Institute of Medical Chemistry, Medical Faculty, Palacký University, 775 15 Olomouc, Czechoslovakia
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Publikationsverlauf

1991

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

N-Deacetylcolchiceine (DAC) administered i.p. to rats decreased the level of serum cholesterol and apoB. It was accompanied by the fall of HDL-C due to the decrease of both HDL subfractions HDLa and HDLb, and by a rather weaker decrease of LDL-C. The levels of serum and lipoprotein triacylglycerols were not significantly affected. The “clearing reaction” to heparin in DAC rats differed from controls with regard to plasma cholesterol resulting in its accumulation in HDLa and LDL simultaneously with an increased activity of post-heparin lipoprotein lipase. These results suggest that the DAC accelerates the lipoprotein cholesterol metabolism.

Key words

N-Deacetylcolchiceine - lipoproteins - cholesterol - heparin - lipase activities

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