Planta Med 1990; 56(2): 152-157
DOI: 10.1055/s-2006-960914
Papers

© Georg Thieme Verlag Stuttgart · New York

Effects of Phaeodactylum tricornutum and Dunaliella tertiolecta Extracts on the Central Nervous System

M. R. Laguna, R. M. Villar, I. Cadavid, J. M. Calleja
  • Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, Galiza, Spain
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Publikationsverlauf

1989

Publikationsdatum:
05. Januar 2007 (online)

Abstract

We report the effects of aqueous extracts of the microalgae Dunaliella tertiolecta Butcher (Chlorophyceae) and Phaeodactylum tricornutum Bohlin (Bacillariophyceae) on oxotremorin-induced cholinergic symptoms, amphetamine-induced hypermotility, pentylenetetrazole-induced convulsions, and Rota-rod test performance. Both extracts significantly reduced rectal temperature, spontaneous motor activity, and time on the Rota-rod and increased the number of mice falling off the rod before 180 s, but neither protected against pentylenetetrazole-induced convulsions or against oxotremorin-induced tremor, salivation, and diarrhoea.

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