Lupeol is the Cytotoxic Principle in the Leaf Extract of Dendropanax cf. querceti

Debra M. Moriarty; Jin Huang; Cherie A. Yancey; Ping Zhang; William N. Setzer; Robert O. Lawton; Robert B. Bates; Sriyani Caldera

doi:10.1055/s-2006-957454

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000058.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Planta Med 1998; 64(4): 370-372
DOI: 10.1055/s-2006-957454

Letters

Lupeol is the Cytotoxic Principle in the Leaf Extract of Dendropanax cf. querceti

Debra M. Moriarty¹ , Jin Huang² , Cherie A. Yancey¹ , Ping Zhang¹ , William N. Setzer² , Robert O. Lawton¹ , Robert B. Bates³ , Sriyani Caldera³

¹Department of Biological Sciences, The University of Alabama in Huntsville, Huntsville, U.S.A.
²Department of Chemistry, The University of Alabama in Huntsville, Huntsville, U.S.A.
³Department of Chemistry, The University of Arizona, Tucson, U.S.A.

Further Information

Publication History

1997

1997

Publication Date:
04 January 2007 (online)

PDF Download Permissions and Reprints

Abstract

The crude ethanol extract from the leaves of Dendropanax cf. querceti (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, and H-4IIE tumor cell lines. The active component has been isolated by activity-directed separation and identified by ¹H- and ¹³C-NMR spectroscopy as the triterpene lupeol. The mechanism of cytotoxic activity of lupeol has been determined to be inhibition of topoisomerase II.

>