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Synthesis 2004(8): 1187-1194  
DOI: 10.1055/s-2004-822347
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 2,3′-Diindolylmethanes and Substituted Indolo[3,2-b]carbazoles

Niklas Wahlströma,b, Birgitta Stenslandc, Jan Bergman*a,b
a Biosciences at NOVUM, Karolinska Institutet, Department of Organic Chemistry, 14157 Huddinge, Sweden
Fax: +46(8)6081501; e-Mail: jabe@biosci.ki.se;
b Södertörn University College, 14104 Huddinge, Sweden
c Preformulation and Biopharmaceutics, Solid State Analysis/SBBG B314:3, Astrazeneca PAR & D, 15185 Södertälje, Sweden
Further Information

Publication History

Received 11 February 2004
Publication Date:
28 April 2004 (online)

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Abstract

Three different synthetic routes to substituted 2,3′-diindolylmethanes, and the syntheses of substituted indolo[3,2-b]carbazoles are described. The first rigid proof of an acylation in the 2-position of a 1,3-unsubstituted indole is also presented in the form of an X-ray structure.

Key words

bisindoles - acylations - Lewis acids - aryl hydrocarbon receptor - indolo[3,2-b]carbazole

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3

Bergander, L.; Rannug, A.; Rannug, U. to be published.

5

Wahlström, N.; Romero, I.; Bergman, J. to be published.

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The crystallographic data of 7h have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication number CCDC 230285. Copies of the data can be obtained free of charge, e-mail: deposit@ccdc.cam.ac.uk.