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Planta Med 2017; 83(03/04): 224-231
DOI: 10.1055/s-0042-111521
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Protective Effects of Puerarin against Aβ 1–42-Induced Learning and Memory Impairments in Mice

Lidan Wu
1   School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China
,
Tong Tong
1   School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China
,
Shutong Wan
1   School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China
,
Tingxu Yan
1   School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China
,
Fangyi Ren
1   School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China
,
Kaishun Bi
2   School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P. R. China
,
Ying Jia
3   School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, P. R. China
› Institutsangaben
Weitere Informationen

Publikationsverlauf

received 13. April 2016
revised 17. Juni 2016

accepted 27. Juni 2016

Publikationsdatum:
15. Juli 2016 (online)

    Lizenzen und Reprints

Abstract

Puerarin is a major isoflavone glycoside from the root of Pueraria lobata. It has been reported that puerarin can protect neurons from oxidative stress-induced apoptosis. Emerging evidence suggests that oxidative damage is associated with Aβ-induced neuronal death. In the current study, we evaluated the effect of puerarin on Alzheimerʼs disease induced by Aβ and explored the potential mechanisms underlying this effect. We found that the escape latency of the Morris water maze was decreased in groups treated with puerarin compared to the model group (p < 0.01). In addition, there were significant differences between treated groups and the model group mice in a Y-maze test (p < 0.01). Furthermore, puerarin recovered the levels of brain-derived neurotrophic factor, phosphorylated tau, malondialdehyde, acetylcholine esterase, glycogen synthase kinase-3beta, and the activity of superoxide dismutase to some extent in the hippocampus and cerebral cortex. Shrinkage of nuclei and swollen and eccentrically dispersed neuronal bodies were observed in the hippocampus of Aβ-treated mice. These data demonstrate that puerarin might protect against cognitive deficits, oxidative stress, and neurodegeneration induced by Aβ 1–42.

Key words

puerarin - Pueraria lobata - Fabaceae - Aβ 1–42 - Alzheimerʼs disease - cognitive impairment

Supporting Information

 

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