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Planta Med 2017; 83(03/04): 217-223
DOI: 10.1055/s-0042-111440
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Guaiane-Type Sesquiterpenoids from Fissistigma oldhamii Inhibit the Proliferation of Synoviocytes

Xue-Ming Zhou
1   Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China
,
Cai-Juan Zheng
1   Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China
,
Yu-Qin Zhang
2   Fujian University of Traditional Chinese Medicine College Of Pharmacy, Fuzhou, Fujian, P. R. China
,
Xiao-Peng Zhang
1   Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China
,
Xiao-Ping Song
1   Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China
,
Wei Xu
2   Fujian University of Traditional Chinese Medicine College Of Pharmacy, Fuzhou, Fujian, P. R. China
,
Guang-Ying Chen
1   Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China
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Publikationsverlauf

received 25. Februar 2016
revised 12. Juni 2016

accepted 26. Juni 2016

Publikationsdatum:
12. Juli 2016 (online)

    Lizenzen und Reprints

Abstract

Three guaiane-type sesquiterpenoids, dysodensiols G–I (1–3), together with five known sesquiterpenoids (4–8) were isolated from the stems of Fissistigma oldhamii (Hemsl.) Merr. Compound 1 represents the first example of an ene(6 → 5)-abeo-14-norguaiane sesquiterpenoid derived from natural products. Their structures were elucidated by a combination of 1D and 2D NMR and MS spectra. The absolute configuration of 2 was determined by an X-ray crystallographic analysis. The inhibitory effect of all compounds on the proliferation of primary synovial cells was evaluated. Compound 3 showed a potent inhibitory effect on the proliferation of synoviocytes with an IC50 value of 1.0 µM.

Key words

Annonaceae - Fissistigma oldhamii (Hemsl.) Merr - guaiane-type sesquiterpenoids - norisoprenoid - synoviocytes

Supporting Information

 

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