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Thromb Haemost 1986; 55(01): 051-053
DOI: 10.1055/s-0038-1661445
Original Article
Schattauer GmbH Stuttgart

Hemostatic Parameters in Newborn - II. Sequential Study During the First Four Weeks of Life

J K Kolindewala
Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
,
B Dube
*   Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
,
V Bhargava
Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
,
R K Dube
*   Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
,
V L N Kota
Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
,
B K Das
Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
› Author Affiliations
Further Information

Publication History

Received 17 April 1985

Accepted 21 October 1985

Publication Date:
19 July 2018 (online)

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Summary

A sequential study of kaolin cephalin clotting time (KCCT), prothrombin time (PT), thrombin time (TT), plasma fibrinogen and serum FDP was conducted during the first four weeks of life on term and preterm babies. A “physiological dip” of PT and TT was noted inappropriate for gestational age (AGA) babies both term and preterm; in case of KCCT, the dip was significant in term AGA babies only. At the end of four weeks, PT and TT had moderately improved in term babies but showed little improvement in preterm ones; KCCT reached almost an adult value in all babies except in preterm AGA and term LGA (large for gestational age) ones. Plasma fibrinogen showed no “physiological dip” and reached adult level in two to four weeks. Serum FDP levels were appreciably raised in preterm AGA babies only at birth and there too normalised by 72 h.

Key words

Neonate - Preterm - Term - SGA - AGA - LGA - Blood coagulation - Hemostasis
 

  • References

  • 1 Jensen AH B, Josso F, Zamet P, Couchard MM, Minkowski A. Evolution of blood clotting factor levels in premature infants during the first 10 days of life: A study of 96 cases with comparison between clinical status and blood clotting factor levels. Pediat Res 1973; 7: 638-644
    CrossrefPubMedGoogle Scholar
  • 2 Ekelund H, Hedner U, Nilsson IM. Fibrinolysis in newborns. Acta Paediat Scand 1970; 59: 33-43
    PubMedGoogle Scholar
  • 3 Kazal LA. Congenital disorders of hemostasis and blood coagulation in infancy. In: The clinical pathology of infancy Sunderman FW, Sunderman jr FW. (Eds) Charles C Thomas; Springfield III: 1967: 103-117
  • 4 Kurkcouglu M, McElfresh AE. The Hageman factor: Determinations of its concentration during the neonatal period and presentation of a case of Hageman factor deficiency. J Pediatr 1960; 57: 61-64
    CrossrefPubMedGoogle Scholar
  • 5 Barnard DR, Simmons MA, Hathaway WE. Coagulation studies in extremely premature infants. Pediat Res 1979; 13: 1330-1335
    CrossrefPubMedGoogle Scholar
  • 6 Dube B, Dube RK, Bhargava V, Kolindewala JK, Kota VL N, Das BK. Hemostatic parameters in newborns. I. Effect of gestation and rate of intrauterine growth. Thromb Haemostas 1986; 55: 47-50
    PubMedGoogle Scholar
  • 7 Cade JF, Hirsh J, Martin M. Placental barrier to coagulation factors, its relevance to the coagulation defect at birth and to haemorrhage in the newborn. Br Med J 1969; 2: 281-283
    CrossrefPubMedGoogle Scholar
  • 8 Aballi AJ, Delamerens S. Coagulation changes in the neonatal period and in early infancy. Pediatr Clin North Am 1962; 9: 785 (quoted by Cade et al, 1969)
    CrossrefPubMedGoogle Scholar
  • 9 Witt I, Müller H, Künzer W. Evidence of existence of foetal fibrinogen. Thrombos Diathes Haemorrh 1969; 22: 101-109
    PubMedGoogle Scholar
  • 10 Hilgartner MW, Smith CH. Plasma thromboplastin antecedent (Factor XI) in the neonate. J Pediatr 1965; 66: 747-752
    CrossrefPubMedGoogle Scholar