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Thromb Haemost 1961; 05(03): 463-473
DOI: 10.1055/s-0038-1654939
Originalarbeiten – Original Article – Travaux Originaux
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Inhibition of Fibrinolysis by Hyperlipemia[*]

Eugene E. Cliffton   **
1   Clotting Mechanisms Section of the Division of Experimental Surgery and Physiology, Sloan-Kettering Institute, New York, N. Y.
2   Dept. of Surgery, Cornell University Medical College, New York, N. Y
,
Albert R. Burchell   ***
1   Clotting Mechanisms Section of the Division of Experimental Surgery and Physiology, Sloan-Kettering Institute, New York, N. Y.
2   Dept. of Surgery, Cornell University Medical College, New York, N. Y
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Publication History

Publication Date:
21 June 2018 (online)

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Summary

1. Parenteral injection of triton produced inhibition of fibrinolysis; this phenomenon correlated with hyperlipemia produced by the triton.

2. Triton induced hyperlipemia caused greater inhibition of fibrinolysis than did cholesterol feedings. It was suggested that this might be related to difference in cholesterol-phospholipid ratio.

3. Saturated fat emulsions produced a greater degree of fibrinolytic inhibition than did unsaturated fat preparations.

* This work was supported by grant # C-3817 of the N. C. I. and # H-2867 of the N. I. H, and institutional funds.


** Associate Professor Clinical Surgery, Cornell University Medical College; and Associate Member, Sloan-Kettering Inst. for Cancer Res. New York, N. Y.


*** Assistant Resident, St. Vincent's Hospital, New York, N. Y.


 

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