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Planta Med 1978; 33(4): 345-349
DOI: 10.1055/s-0028-1097389
DOI: 10.1055/s-0028-1097389
Research Articles
© Georg Thieme Verlag Stuttgart · New York
Hormonal Profile of Coronaridine Hydrochloride – an Antifertility Agent of Plant Origin1
1 Communication no. 2350.Further Information
Publication History
Publication Date:
13 January 2009 (online)
Abstract
The hormonal properties of coronaridine hydrochloride were investigated. A single oral administration of the compound (30 mg/kg) prevented pregnancy in rats when given on days 1, 2, 3 or 4 post–coitum; the effect on days 5, 6, 7 or 8 of pregnancy was, however, partial. The substance showed estrogenic activity but was devoid of antiestrogenic, androgenic, antiandrogenic, progestational, antiprogestational and uterine stimulant activities; however, there was a partial inhibition of oxytocin–induced uterine response. Coronaridine appears to exert its antifertility action due to its frank estrogenicity.
Key Word Index
Coronaridine hydrochloride - Antifertility Action - Oestrogenic Activity