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Planta Med 2021; 87(12/13): 1025-1031
DOI: 10.1055/a-1472-6336
Natural Product Chemistry and Analytical Studies
Original Papers

Chemical Characterisation-Biological Evaluation of Greek Cultivar Cardoon Seeds (Cynara cardunculus). A By-product with Potential High Added Value[ # ]

Konstantia Graikou
1   Laboratory of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National & Kapodistrian University of Athens, Athens, Greece
,
Panagiota-Maria Kourti
1   Laboratory of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National & Kapodistrian University of Athens, Athens, Greece
,
Gokhan Zengin
2   Department of Biology, Science Faculty, Selcuk University, Konya, Turkey
,
Olga Gortzi
3   Department of Agriculture Crop Production and Rural Environment, University of Thessaly, Volos, Greece
,
Nikolaos Danalatos
3   Department of Agriculture Crop Production and Rural Environment, University of Thessaly, Volos, Greece
,
Ioanna Chinou
1   Laboratory of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National & Kapodistrian University of Athens, Athens, Greece
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Abstract

Cynara cardunculus (artichoke) is a perennial plant of the Mediterranean basin, known since antiquity as food and for its therapeutic properties. Cynara is a relatively small genus with two cultivated species and one wild one. Recently, successful efforts have been made to cultivate wild cardoon and monetise it as a bioenergy crop. In this study, the seeds of an established Greek cultivar of C. cardunculus, cultivated in the experimental field and used as biofuel, have been researched for their chemical profile and nutritional value. According to the results, six lignans were isolated [arctigenin, arctiin, trachelogenin, tracheloside, cynarinine, and ethylate of trachelogenin (isolated for the first time from a natural source)] as well as the most characteristic metabolites of the genus (linoleic acid, trilinolein, and 3,5-dicaffeoylquinic acid). Moreover, the total phenolic content (31.18 – 54.51 mg gallic acid equivalents/g extract) and antioxidant and enzyme inhibitory activities of the seeds have been evaluated and showed strong antioxidant properties (44.42 – 516.81 mg gallic acid equivalents/g extract) as well as satisfactory bleaching (enzyme tyrosinase, 16.95 – 23.80 mg kojic acid equivalents/g extract), antidiabetic (enzymes a-amylase, a-glucosidase, 0.14 – 1.75 mmol acarbose equivalents/g extract), and protective against neurodegenerative disease (cholinesterase enzymes, 0.49 – 1.22 mg galanthamine equivalents/g extract) activities. The nutritional evaluation of the seeds confirmed them as a rich source of unsaturated fatty acids, dietary fibre (24.1%), and high protein content (19.3%). It is noteworthy that such a neglected bioactive by-product, with essentially high nutritional value, as the studied seeds could be investigated for its value-added applications towards food and food supplements areas.

Key words

Cynara cardunculus Greek hybrid - Asteraceae - lignans - biological evaluation - nutritional value

# Dedicated to Professor Arnold Vlietinck on the occasion of his 80th birthday.


Supporting Information



Publication History

Received: 28 December 2020

Accepted after revision: 25 March 2021

Article published online:
26 April 2021

© 2021. Thieme. All rights reserved.

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