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Synthesis 2004(3): 436-440  
DOI: 10.1055/s-2004-815924
PAPER
© Georg Thieme Verlag Stuttgart · New York

Solvent-Free Synthesis of 6-Arylbenzimidazo[1,2- c ]quinazolines under Microwave­ Irradiation

Hernán Pessoa-Mahana*a, C. David Pessoa-Mahanab, Ricardo Salazara, Jaime A. Valderramac, Edmundo Saezb, Ramiro Araya-Maturanaa
a Departamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Casilla 233, Santiago 1, Chile
Fax: +56(2)6782868; e-Mail: hpessoa@ciq.uchile.cl;
b Departamento de Farmacia, Pontificia Universidad Católica de Chile, Casilla 306, Santiago, Chile
c Departamento de Química Orgánica, Facultad de Química, Pontificia Universidad Católica de Chile, Casilla 306, Santiago, Chile
Further Information

Publication History

Received 16 October 2003
Publication Date:
26 January 2004 (online)

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Abstract

The syntheses of 2-(2-nitrophenyl)-1-benzoyl-1H-benzimidazole derivatives 5-9 and their reduction to the corresponding 2-benzimidazoylbenzamides 10-13 are described. Compounds 10-13 were cleanly and efficiently converted to the corresponding 6-arylbenzimidazo[1,2-c]quinazolines 17-20 by microwave activation using SiO2-MnO2 as solid inorganic support.

Key words

benzimidazoles - heterocyclization - microwaves - benzimidazoquinazolines - solvent-free reactions

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