Synthesis and Reactivity of 2-Acyl-1,3-selenazoles

Abstract

2-Acyl-1,3-selenazoles were prepared in two steps from α-bromoketones and seleno amides. The base mediated fragmentation of these compounds afforded 2-unsubstituted 1,3-selenazoles. The reaction of 2-acyl-1,3-selenazoles with hydroxylamine hydrochloride afforded oximes which were transformed into 2-carba­moyl-1,3-selenazoles by a regioselective Beckmann rearrangement.

Key words

cyclization - fragmentation - selenium heterocycles - rearrangement - 1,3-selenazoles

References

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