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Thromb Haemost 1960; 4(03): 473-481
DOI: 10.1055/s-0038-1654529
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Activation of Fibrinolysis in Guinea-Pig Serum by Bile Acids

E. S Olesen
1   Biological Institute of the Carlsberg Foundation, Copenhagen
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Publication History

Publication Date:
17 June 2018 (online)

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Summary

Various bile acids produced fibrinolytic activity in guinea-pig serum under similar conditions as previously established for various anionic polyelectrolytes [Olesen (1959 b,c)].

“Tauroglycocholate“ furthermore produced fibrinolytic activity by simple addition to guinea-pig serum.

These reactions probably depend on polyanion interactions with active and/or inhibitory components of the fibrinolytic system.

The observations suggest that bile acids could be involved in producing fibrinolytic activity in the biliary system.

 

  • References

  • (1) Albrechtsen O. K. The fibrinolytic activity of human tissues. Brit. J. Haemat. 3: 284 1957;
    CrossrefPubMedGoogle Scholar
  • (2) Astrup T. The biological significance of fibrinolysis. Lancet ii: 565 1956;
    PubMedGoogle Scholar
  • (3) Astrup T, Müllertz S. The fibrin plate method for estimating fibrinolytic activity. Arch. Biochem. 40: 346 1952;
    CrossrefPubMedGoogle Scholar
  • (4) Astrup T, Olesen E. Partial purification and fibrinolytic effect of a factor in peptone. Dan. med. Bull. 4: 159 1957;
    PubMedGoogle Scholar
  • (5) Astrup T, Sterndorff I. A fibrinolytic system in human milk. Proc. Soc. exp. Biol. (N.Y.) 84: 605 1953;
    CrossrefPubMedGoogle Scholar
  • (6) Benedetti-Valentini S, Luminari M. Esiste un potere fibrinolitico nella bile?. Minerva med. (Torino) 48: 2462 1957;
    PubMedGoogle Scholar
  • (7) Ekwall P, Lindström E. V, Sëtakä J. The stability of the micelles in bile acid salt solutions of different acidities. Acta chem. scand. 5: 990 1951;
    CrossrefPubMedGoogle Scholar
  • (8) Lassen M. Heat denaturation of plasminogen in the fibrin plate method. Acta physiol. scand. 27: 371 1952;
    PubMedGoogle Scholar
  • (9) Olesen E. S. Fibrinolytic activity produced with peptone and other agents. Transactions of the 6th Congress of the European Society of Haematology, Copenhagen. 1957: 430 S. Karger; Basel.:
    Google Scholar
  • (10) Olesen E. S. Peptone activation of a serum fibrinolytic system. Acta pharmacol. (Kbh.) 15: 197 1959; a
    PubMedGoogle Scholar
  • (11) Olesen E. S. Effect of acid polysaccharides on the fibrinolytic system in guinea-pig serum. Acta pharmacol. (Kbh.) 15: 307 1959; b
    PubMedGoogle Scholar
  • (12) Olesen E. S. Effect of anionic polyelectrolytes on the fibrinolytic system of guinea-pig serum. Acta pharmacol. (Kbh.) 16: 38 1959; c
    PubMedGoogle Scholar