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Thromb Haemost 1960; 4(02): 283-288
DOI: 10.1055/s-0038-1654507
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Thromboplastic Activity of Split Products of Phosphatidyl Ethanolamine

Karl H. Slotta
1   Departments of Biochemistry and Medicine, University of Miami School of Medicine, Coral Gablesy, Florida, and I. Medizin. Universitätsklinik Wien, Austria
,
Erwin Deutsch
1   Departments of Biochemistry and Medicine, University of Miami School of Medicine, Coral Gablesy, Florida, and I. Medizin. Universitätsklinik Wien, Austria
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Publication History

Publication Date:
26 July 2018 (online)

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Summary

Pure synthetic L-α-(dioleoyl) PE is inactive as a platelet substitute in the thromboplastin generation test, even when in a stable suspension. Under humid conditions it is partly hydrolyzed. Among the split products lyso PE and phosphoryl ethanolamine were identified. The resulting mixture has thromboplastin generating activity. This thromboplastin is formed slowly, but it is stable over longer periods of time than thromboplastins formed from PS + PC or PS + PE mixtures, which are rapidly generated and lose activity faster.

 

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